THE 2-MINUTE RULE FOR TRAMADOL (RETARD)

Opioid action is due to equally small affinity binding of the guardian compound and better affinity binding in the O-demethylated metabolite M1 to μ-opioid receptors. In animal versions, M1 is as many as 6 instances extra powerful than tramadol in producing analgesia and two hundred times extra strong in μ-opioid binding.Although significantly le